Average eccentricity showed a trend toward a higher value with increasing age (r 2 = 0.48, p = 0.004), and was higher in the older group, signifying that cells had a more elongated shape as they aged ( Table 9 , p = 0.01; Figure 8D ).
The percent of hexagonal cells showed a decreasing trend with age (r 2 = 0.31, p = 0.03), and when older and younger groups were compared, the percent of hexagonal cells was higher in the younger group ( Table 8 , p = 0.01; Figure 8C ).
An overall trend of decreasing RPE cell density with age was observed in the macula (r 2 = 0.32, p = 0.03; Figure 8A ).
There was a clear trend of increasing eccentricity from the macula toward the far periphery, increasing by 38% ( Figure 4D ).