Dynamic of Mixed HCV Infection in Plasma and PBMC of HIV/HCV Patients Under Treatment With Peg-IFN/Ribavirin.

Multivariate analysis (Table, Supplemental Content 3, http://links.lww.com/MD/A485 ) showed that HCV MG reported a significant negative impact on the probability of treatment response (regression coefficient associated to HCV MG = −3.815, Table, Supplemental Content 3, http://links.lww.com/MD/A485 ), which can be interpreted as a significant reduction of the probability of response of 0.022 (OR = 0.022, 95% CI = [0.001–0.602]; P = 0.029), whereas HCV–RNA levels (evaluated as unitary increase) showed a trend toward significance (OR 0.17, 95% CI, OR 0.025–1.231; P = 0.07).

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By multivariate analysis we showed that the probability of response to P–R treatment was negatively and significantly affected mainly by an MG, whereas HCV load showed a trend toward significance and HCV infecting genotype per se together with HCV–RNA positivity in PBMC did not reach statistical significance.

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