Free versus Fixed Combination Antihypertensive Therapy for Essential Arterial Hypertension: A Systematic Review and Meta-Analysis.

PLoS One · 2016 · PMC4993355 · PMID 27548060

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a significant trendno p-value reported

As stated above, the results of these previously published systematic reviews showed a significant trend towards increased compliance to therapy favoring the fixed combination therapy, however these results were largely based on retrospective data.

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did not reach statistical significanceno p-value reported

Likewise, the analysis showed a 20% decrease in adverse events favoring the fixed combination group, that did not reach statistical significance (OR: 0.80 [95% CI: 0.58 to 1.11]).

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a nonsignificant trendno p-value reported

The results of the pooled analysis of the three trials showed a nonsignificant trend towards better blood pressure control (risk ratio 1.11 95% CI 0.92, 1.33) favoring the fixed combination group.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.