Progressive natural killer cell dysfunction associated with alterations in subset proportions and receptor expression in soft-tissue sarcoma patients.

For granzyme B, patient and donor groups showed comparable proportions of positive cells, and NK cells from RCC patients showed a trend toward higher percentages of granzyme B + cells compared to HD (median 83% vs. 63%; Figs. 4A and B , middle panels).

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Yet, alterations in 1st-line STS patients were moderate and did not reach statistical significance, thus they cannot convincingly explain the poor cytotoxicity of NK cells of 1st-line STS patients.

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