Effects of MDMA on body temperature in humans.

34 Peripheral body temperature was significantly increased by 0.4°C compared with placebo in male subjects, whereas MDMA-induced increases in body temperature did not reach statistical significance in the smaller group of female participants. 34 All axillary body temperatures remained below 38°C. 34 In our more recently published placebo-controlled studies performed in Basel, Switzerland, core body temperature was measured using an ear thermometer and repeatedly after the administration of MD

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Skin temperature was markedly increased in the hot and decreased in the cold environment, and MDMA produced a near-significant increase in skin temperature under both temperature conditions and compared with placebo. 50 Altogether, considering the pooled data analyses from our laboratory and those of the Freedman study, MDMA is well documented to produce an acute and dose-dependent elevation in core body temperature in healthy subjects.

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