showed a trendp = 0.09
Left hemisphere Average left cortical surface area showed a trend toward significant decrease between patients (mean, 2627.9 mm 2 ± 277.68) and controls (mean, 2779.4 mm 2 ± 269.65) ( p = 0.09, uncorrected).
Left hemisphere Average left cortical surface area showed a trend toward significant decrease between patients (mean, 2627.9 mm 2 ± 277.68) and controls (mean, 2779.4 mm 2 ± 269.65) ( p = 0.09, uncorrected).
The left middle temporal surface area was the most significant predictor of performance with standardized coefficient β = 0.90, p = 0.005 ( Figure 3B , left panel); only the left precentral area showed a trend toward significance with β = -0.496, p = 0.09.
However, given that our CD patients were closely matched to healthy control subjects in age, gender, handedness, and education, we believe that the findings reported here with respect to brain morphological changes merit further investigation with larger sample sizes to more clearly elucidate some of the findings that failed to reach statistical significance after correcting for multiple comparisons.