Meta-analysis of Genome Wide Association Studies Identifies Genetic Markers of Late Toxicity Following Radiotherapy for Prostate Cancer.

The most statistically significant SNPs associated with late toxicity are listed in Table 5 , Table 6 , Table 7 , Table 8 , which show several SNPs had meta-p-values reaching or approaching significance (p-value ≤ 5 × 10 − 6 ) with concordant effect direction across the individual studies.

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There were no genome-wide significant SNPs associated with rectal bleeding, and though several approached significance, these require investigation in future larger studies.

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