Exposure to the Functional Bacterial Amyloid Protein Curli Enhances Alpha-Synuclein Aggregation in Aged Fischer 344 Rats and Caenorhabditis elegans.

Serum TLR2 levels were trending higher in the rats exposed to curli than the other two groups but the differences did not reach statistical significance ( Supplementary Figure 3 ).

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Swimming tests were also performed to evaluate locomotive activity and showed a trend toward decreased thrashing rate (~15–20%) in worms exposed to wild-type curli-producing E . coli vs. mutant E . coli lacking curli, which did not reach statistical difference (data not shown).

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