Prognostic Value of Pre-operative Renal Insufficiency in Urothelial Carcinoma: A Systematic Review and Meta-Analysis.

Sci Rep · 2016 · PMC5057078 · PMID 27725745

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did not reach statistical significanceno p-value reported

In a subgroup analysis stratified by recurrence location of upper urinary tract urothelial carcinoma, pre-operative renal insufficiency was a risk factor for recurrence in contralateral upper urinary tract (HR = 2.69), although the risk for recurrence in bladder was similar, it did not reach statistical significance.

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failed to reach statistical significanceno p-value reported

This may explain that in our meta-analysis, the risk factors of pre-operative renal insufficiency for recurrence of upper urinary tract urothelial carcinoma were similar when calculated using eGFR value (HR = 2.56) and using serum creatinine (HR = 2.05), but the latter failed to reach statistical significance due to great between-study variability.

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