Long-term administration of the mitochondria-targeted antioxidant mitoquinone mesylate fails to attenuate age-related oxidative damage or rescue the loss of muscle mass and function associated with aging of skeletal muscle.

Muscle from mitoquinone mesylate-treated old mice showed a trend toward a reduction ( P = 0.09) in OGG1 protein levels ( Fig. 3 C , right and lower), with no change in the levels of 8-OHdG ( Fig. 3 C , left).

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2 C ) but did not reach statistical significance.

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