Targeting of PI3K/AKT/mTOR pathway to inhibit T cell activation and prevent graft-versus-host disease development.

J Hematol Oncol · 2016 · PMC5072323 · PMID 27765055

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a clear trendno p-value reported

In both populations, increasing doses of the inhibitors induced a clear trend toward a decrease in the percentage of IFN-γ + and granzyme B + cells (Fig. 4a , b ).

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showed a trendno p-value reported

The percentage of the other subpopulations hardly changed in the presence of the drugs, except the percentage of T CM cells among CD4 + population, which showed a trend to decrease with stimulation, and to recover the value of unstimulated control when the drugs were added (Additional file 1 : Figure S1).

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