A Large Genome-Wide Association Study of Age-Related Hearing Impairment Using Electronic Health Records.

PLoS Genet · 2016 · PMC5072625 · PMID 27764096

Europe PMC DOI

hedged sentences

0.0410

closest p · 0.8× alpha

0.0500

boldest claim

The sentences

marginally significantp = 0.041actually significant

The second SNP, rs9493627, replicated in the UK Biobank (p = 0.0095), the other GERA race/ethnicity groups (p = 0.0080), and was marginally significant and in the correct direction for SRT (p = 0.041) and suggestively so for SDS (p = 0.081).

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a suggestive trendp = 0.044actually significant

For three of the SNPs, there was no pattern towards earlier onset for the predisposing allele (rs4932196 p = 0.24, rs58389158 p = 0.75, rs2877561 p = 0.97); however, for SNP rs9493627 in EYA4, there was a suggestive trend (p = 0.044) towards earlier onset with the number of risk alleles.

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of marginal significancep<0.05actually significant

No SNP reached a Bonferroni corrected threshold of 0.00086, with only three SNPs being of marginal significance 0.01<p<0.05 ( S1 Table ).

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