A 13% decrease in PEG3 expression was observed in placentas from participants with an EPDS score ⩾13, highlighting them as at risk of a depressive disorder, although this difference did not reach statistical significance ( p = 0.16) possibly due to the relatively small number of women scoring above this cut-off ( n = 9).
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Maternal prenatal depression is associated with decreased placental expression of the imprinted gene PEG3.
2
0.1600
0.1600
The sentences
Despite promising pilot data, the modest correlation between placental PEG3 expression and maternal prenatal EPDS scores ( r = −0.23, p = 0.16, n = 40) failed to reach statistical significance.