Spatial transcriptome analysis reveals Notch pathway-associated prognostic markers in IDH1 wild-type glioblastoma involving the subventricular zone.

BMC Med · 2016 · PMC5080721 · PMID 27782828

Europe PMC DOI

hedged sentences

0.0560

closest p · 1.1× alpha

0.0860

boldest claim

The sentences

a clear trendp = 0.056so close (0.05 < p ≤ 0.1)

Identification of prognostic markers distinctive of SVZ+ GBM In our validation cohort of 142 patients with IDH wt GBM, age at first diagnosis, radiotherapy, adjuvant chemotherapy, preoperative KPS and GTR, together with a clear trend for SVZ involvement ( p = 0.056; HR 1.39 (0.99–1.96)), were predictive for OS, while age at first diagnosis and adjuvant chemotherapy were predictive for PFS (Table 5 ).

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a strong trendp = 0.086so close (0.05 < p ≤ 0.1)

In group II GBMs, there was also a strong trend for upregulation of DLL3 ( p = 0.086) and NTRK2 ( p = 0.056) and downregulation of PIR ( p = 0.05) (Table 4 ; Fig. 3a, b ).

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