Bone loss and aggravated autoimmune arthritis in HLA-DRβ1-bearing humanized mice following oral challenge with Porphyromonas gingivalis.

Arthritis Res Ther · 2016 · PMC5081677 · PMID 27784339

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showed a trendno p-value reported

gingivalis showed a trend towards decreased bone density relative to manus from unbrushed control mice, but once arthritis was triggered both groups demonstrated an enhanced bone loss that resulted in destruction of the form and function of the bones analyzed.

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did not reach statistical significanceno p-value reported

While it did not reach statistical significance, treatment with P. gingivalis triggered a trend towards bone loss in the absence of clinically detectable autoimmune arthritis.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.