Atheroprotective effects of pure tocotrienol supplementation in the treatment of rabbits with experimentally induced early and established atherosclerosis.

T3–15 mg/kg group showed a reduction trend but did not reach statistical significance when compared to T3-negative rabbits group (mean±SEM: 2.4±0.9% vs. 6.6±1.4% p =0.1).

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B2 showed a trend in atherosclerotic lesion area reduction in both 4 mg/kg and T3–15 mg/kg treatment groups but did not reach statistical significance (mean±SEM: 525±3.6% vs. 69.2±14.0% p =1.0 and 43.6±12.0% vs. 69.2±14.0% p =1.15 respectively).

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These consistent findings suggest that in early atherosclerosis, changes in MMP-9 following treatment with T3 may not be significant enough as they are not overly expressed following HCD.

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