In the study from the Mayo clinic 26 , current smokers had double the risk of cardiovascular death compared to never smokers, although this finding did not reach statistical significance (HR 1.98 [95% CI 0.93, 4.24]), perhaps because the study was underpowered (603 patients).
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Smoking-Related Mortality in Patients With Early Rheumatoid Arthritis: A Retrospective Cohort Study Using the Clinical Practice Research Datalink.
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The SHRs for all‐cancer and respiratory deaths were similar to those for circulatory disease but failed to reach statistical significance, while the risk of death due to respiratory infection was found to decrease for each year of cessation in former light smokers only.