Parameters of Stromal Activation and Epithelial to Mesenchymal Transition as Predictive Biomarkers for Induction Chemotherapy in Patients With Locally Advanced Oral Cavity and Oropharyngeal Squamous Cell Cancer.

Clin Exp Otorhinolaryngol · 2016 · PMC5115147 · PMID 27416733

Europe PMC DOI

hedged sentences

0.0610

closest p · 1.2× alpha

0.0610

boldest claim

The sentences

showed a trendP =0.061so close (0.05 < p ≤ 0.1)

Of the investigated histological parameters and biomarkers only a low membrane-bound expression of E-cadherin showed a trend to be associated with incomplete response to IC ( P =0.061).

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did not reach statistical significanceno p-value reported

This might explain why some well-known negative prognostic factors for overall survival like T and N classification did not reach statistical significance although the related Kaplan-Meier curves take a completely different and separated course.

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a statistical trendno p-value reported

When considering all patients, only low E-cadherin expression showed a statistical trend to be correlated to incomplete pathological response.

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