Chronic Alcohol Ingestion Delays T Cell Activation and Effector Function in Sepsis.

Results indicated a strong trend toward increased serum IL-4 in the EtOH-fed septic relative to water-fed septic animals (p = 0.05, Fig 11B ), and a statistically significant increase in both IL-6 and IL-10 in the sera of EtOH-fed septic relative to water-fed septic animals ( Fig 11E and 11F ).

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There was a trend toward increased absolute number of CD4+ T cells in the EtOH sham group, which appears reduced in the setting of sepsis, but this did not reach statistical significance due to intragroup variability ( Fig 2B ).

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We observed a significant decrease in the absolute number of CD4 + T cells in the EtOH CLP group compared with EtOH sham at 72h post-CLP, while the decrease in CD4 + T cells in the water-fed CLP animals relative to water-fed sham controls failed to achieve significance.

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Within 24h, there was a significant increase in the frequency of CD69+CD43+ cells within the CD44 lo CD4+ T cell population in water sepsis, while the increase in alcohol sepsis failed to reach significance.

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