Alternative BCG delivery strategies improve protection against Mycobacterium tuberculosis in non-human primates: Protection associated with mycobacterial antigen-specific CD4 effector memory T-cell populations.

Tuberculosis (Edinb) · 2016 · PMC5120991 · PMID 27865390

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closest p · 1.1× alpha

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approaching significancep = 0.055so close (0.05 < p ≤ 0.1)

At this time-point, frequencies of antigen-specific TransEM cells measured in the IV vaccinated animals appeared lower than those of the other treatment groups, approaching significance in relation to the unvaccinated controls and ID vaccinated animals ( p = 0.055 and 0.078, respectively).

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approached significancep = 0.055so close (0.05 < p ≤ 0.1)

However, the frequency of antigen-specific TransEM cells measured in the unvaccinated controls was significantly greater than that observed in the IV BCG vaccine group ( p = 0.016 ), and approached significance relative to ID + IT and ID BCG vaccinated animals ( p = 0.055 and 0.078, respectively), at study week 25. 3.6.4 Correlations between immunological assays The ex vivo IFN-γ ELISpot assay applied throughout this study is commonly assumed to provide a rapid readout of Th1 effector T-cell function.

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