Macrophage-dependent IL-1β production induces cardiac arrhythmias in diabetic mice.

In a similar manner compared with an earlier study 22 , we have observed a trend towards lower insulin levels in Tlr2 −/− diabetic compared with Tlr2 −/− non-diabetic mice (unpaired t -test; P =0.07) ( Supplementary Table 1 ), although the difference did not reach statistical significance.

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Nevertheless, the circulating insulin levels in diabetic IL-1r −/− were significantly decreased compared with non-diabetic counterparts, while a strong trend towards decreased levels was found in diabetic Tlr2 −/− and Casp1 −/− mice, even though it was not statically different.

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