Angiotensin-converting enzyme 2 is reduced in Alzheimer's disease in association with increasing amyloid-β and tau pathology.

The ACE-1/ACE-2 ratio also correlated positively with insoluble Aβ level, approaching significance ( r = 0.199, P = 0.059) (Fig. 3c ), and significantly with p-tau ( r = 0.252, P < 0.05) (Fig. 3d ).

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ACE-2 activity also differed significantly between ACE1 (rs1799752) indel genotypes ( P < 0.05), with individuals who were homozygous II for ACE-1 (previously associated with increased risk for AD [ 17 ]) having the lowest ACE-2 activity, although post hoc analysis revealed that this did not reach statistical significance (Fig. 2b ).

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