Pharmacologic modulation of RORγt translates to efficacy in preclinical and translational models of psoriasis and inflammatory arthritis.

Sci Rep · 2016 · PMC5131364 · PMID 27905482

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did not reach statistical significanceno p-value reported

At the RNA level, JNJ-54271074 significantly inhibited expression of IL-17F, IFNγ and IL-6, and at 30 and 60 mg/kg suppressed IL-17A, IL-22 and TNFα although these effects did not reach statistical significance ( Fig. 7E ).

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showed a trendno p-value reported

The same concentration of JNJ-54271074 showed a trend of decreasing IL-22, TNFα and GM-CSF production, while slightly increasing IFNγ production.

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