Diabetes negatively affects cortical and striatal GABAergic neurons: an effect that is partially counteracted by exendin-4.

Biosci Rep · 2016 · PMC5137538 · PMID 27780892

Europe PMC DOI

hedged sentences

0.0001

closest p · 0.0× alpha

0.0900

boldest claim

The sentences

highly significantP <0.0001actually significant

T2D reduces the density of CB-positive neurons in the neocortex and striatum The assessment of the density of CB-positive neurons showed a highly significant interaction between age and diabetes in the two-way ANOVA analysis ( P <0.0001) indicating the effect of diabetes on this marker.

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a notable trendP =0.09so close (0.05 < p ≤ 0.1)

did not reach statistical significanceno p-value reported

However, there was a notable trend ( P =0.09) towards the reduction in the density of PV-positive neurons in 13-month-old GK rats in comparison with 3-month-old GK rats (16% reduction) although this did not reach statistical significance ( Figures 5 B and 5 D).

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a strong trendno p-value reported

However, the average PV-positive cell volume in the 13-month-old Wistar showed a strong trend towards an increase in comparison with 3-month-old Wistars ( Figures 6 A and 6 C).

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failed to reach significanceno p-value reported

In the striatum, there was a noticeable trend towards the reduction in CR-positive cell density in 13-month-old GK rats compared with 3-month-old GK rats (a 32% reduction), which failed to reach significance after correction for multiple comparisons ( Figures 4 B and 4 D).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.