Is β-Lactam Plus Macrolide More Effective than β-Lactam Plus Fluoroquinolone among Patients with Severe Community-Acquired Pneumonia?: a Systemic Review and Meta-Analysis.

J Korean Med Sci · 2017 · PMC5143302 · PMID 27914135

Europe PMC DOI

hedged sentences

0.4400

closest p · 8.8× alpha

0.4400

boldest claim

The sentences

did not reach statistical significanceP = 0.44not close (p > 0.1)

In addition, a pooled estimate from three observational trials with a relatively high quality of study and one RCT did not reach statistical significance between the two treatment groups (OR, 0.89; 95% CI, 0.66 to 1.20; P = 0.44; I 2 = 38.0%, not shown) ( 15 , 17 , 21 , 22 ).

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showed a trendno p-value reported

A random effect showed a trend toward superiority of BL-M therapy, but its estimate did not reach statistical significance, and heterogeneity between trials was high (OR, 0.75; 95% CI, 0.46 to 1.21; P = 0.23; I 2 = 76.0%).

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