RNA sequencing of chorionic villi from recurrent pregnancy loss patients reveals impaired function of basic nuclear and cellular machinery.

Sci Rep · 2016 · PMC5143936 · PMID 27929073

Europe PMC DOI

hedged sentences

0.1620

closest p · 3.2× alpha

0.1620

boldest claim

The sentences

showed a trendP = 0.162not close (p > 0.1)

Additionally, Taqman RT-qPCR analysis showed a trend for an increased expression of the Complement Component 3 (C3 ) gene, concordant with the RNA-Seq dataset (fc = 3.57, P = 0.162; Supplementary Fig.

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did not reach statistical significanceno p-value reported

However, this outcome did not reach statistical significance possibly due to differences in the study material composition (RNA-Seq: microdissected chorionic villi; Taqman RT-qPCR: placental samples comprised of variable cell types).

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highly significantno p-value reported

The two seminal studies using gene expression microarray profiling of placental samples from RPL cases detected no differentially expressed genes with highly significant statistical support.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.