a clear trendp = 0.07
3×Tg-AD mice immunized with 77E9 antibody also showed a clear trend (unpaired t test, 3×Tg-IgG vs. 3×Tg-77E9, p = 0.07) toward spending more time exploring the object at a novel location than did the mouse IgG-treated control mice (Fig. 3b ).