Efficacy and Safety of Plasma Exchange with 5% Albumin to Modify Cerebrospinal Fluid and Plasma Amyloid-β Concentrations and Cognition Outcomes in Alzheimer's Disease Patients: A Multicenter, Randomized, Controlled Clinical Trial.

Aβ levels in CSF Variation of Aβ 1–42 levels in CSF between the end of the last PE and baseline (primary efficacy variable) showed a higher adjusted (least-squares) mean for the PE-treated group compared to the control group, approaching significance ( p = 0.072), with values of 75.3 pg/mL (95% CI: –19.8, 170.5) for the PE-treated group versus –45.5 pg/mL (95% CI: –135.1, 44.2) for the control group.

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2 ), the difference in the change at baseline versus the last PE between the two groups of patients was only close to the level of significance, a trend of increase that was also observed in the preliminary phase I studies [ 22 ].

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