Late-Onset Cognitive Impairments after Early-Life Stress Are Shaped by Inherited Differences in Stress Reactivity.

Front Cell Neurosci · 2017 · PMC5306385 · PMID 28261058

Europe PMC DOI

hedged sentences

0.0010

closest p · 0.0× alpha

0.0960

boldest claim

The sentences

highly significantp < 0.001actually significant

The difference between the three lines became highly significant after 15 min of restraint ( F 2,53 = 140.272, p < 0.001, post hoc tests: all p < 0.001), when, in addition, there was also an interaction of line and condition ( F 2,53 = 3.468, p = 0.038).

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a strong trendp = 0.057so close (0.05 < p ≤ 0.1)

response) ( F 1,53 = 1957.027, p < 0.001) and the initial CORT values showed a strong trend for a main effect of line ( F 2,53 = 3.023, p = 0.057, post hoc tests: HR vs.

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showed a trendp = 0.058so close (0.05 < p ≤ 0.1)

Animals tested in late adulthood showed a trend for a main effect of mouse line regarding the time spent in the inner zone of the OF ( F 2,54 = 3.002, p = 0.058, post hoc tests: HR vs.

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a statistical trendp = 0.096so close (0.05 < p ≤ 0.1)

In addition, the effect of ELS housing was still significant ( F 1,65 = 5.331, p = 0.024), and post hoc tests showed a statistical trend in the LR line ( p = 0.096) ( Figure 1G ).

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