Spatial distribution of FoxP3+ and CD8+ tumour infiltrating T cells reflects their functional activity.

However, with regard of NED-survival high epithelial CD8+ counts showed a slight trend to a favourable prognosis (p = 0.099) and in the stromal compartment there was a distinct association with an improved prognosis (p = 0.001) ( Supplementary Figure 2 F, H ).

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Accordingly, we could show that short intercellular distances in the epithelial compartment showed a trend towards a favourable prognosis, whereas in the stromal compartment long distances predicted an improved prognosis.

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In contrast, short FoxP3+-CD8+ distances and short CD8+-FoxP3+ distances in the epithelial compartment post-RCT were associated with a clear trend to an inferior outcome (Figure 4C , supplementary Figure 4 E, F and 5 C ).

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