Upregulation of the endothelin A (ET_A) receptor and its association with neurodegeneration in a rodent model of glaucoma.

After 2 weeks of IOP elevation, immunohistochemical analysis of retinal sections from rat eyes showed an increasing trend in immunostaining for ET A receptors in multiple retinal layers including the inner plexiform layer, ganglion cell layer and outer plexiform layer.

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Empty vector transfected cells treated with 100 nM ET-1 (Abs = 0.310 ± 0.014) or 100 nM ET-3 (Abs = 0.289 ± 0.023) for 24 h showed a decreasing trend in absorbance readings compared to untreated empty vector cells (Abs = 0.328 ± 0.019) though not statistically significant (Fig. 4 a).

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There was a trend towards an increase of the SubG peak in ET A vector cells compared to empty vector cells although it did not reach statistical significance (10.20 ± 1.42 vs. 4.96 ± 0.57%, n = 3).

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While five out seven rats showed an increase in immunostaining for the ET A receptors, two of the seven rats showed a slight decrease, thereby did not attain statistical significance at the 2 week time point of IOP elevation (retina, RFI = 1.57 ± 0.34; OPL, RFI = 1.40 ± 0.28; IPL, RFI = 1.51 ± 0.33; GCs, RFI = 2.40 ± 0.98; NFL, RFI = 1.54 ± 0.46), however there was a clear trend towards an increase in immunostaining for ET A receptors (Fig. 1 c).

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