Toxicity profile of approved anti-PD-1 monoclonal antibodies in solid tumors: a systematic review and meta-analysis of randomized clinical trials.

Oncotarget · 2017 · PMC5352453 · PMID 27852042

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did not reach statistical significanceP = 0.067so close (0.05 < p ≤ 0.1)

showed a trendno p-value reported

[ 12 – 15 ] RR for all grade serious AEs showed a trend favoring anti-PD-1 treatment but did not reach statistical significance (RR 0.56, 95%CI 0.31-1.04; P = 0.067).

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