Impact of Grapefruit Juice on the Antiplatelet Activity of Loading and Maintenance Doses of Clopidogrel in Healthy Volunteers.

However, the differences in the proportions of volunteers with high on-treatment platelet reactivity with grapefruit juice failed to reach statistical significance.

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There was a trend suggesting an effect of grapefruit juice on the mean PRU values with the maintenance dose of clopidogrel, but this difference did not reach statistical significance compared to ingestion with water.

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