A comparative analysis of the foamy and ortho virus capsid structures reveals an ancient domain duplication.

BMC Struct Biol · 2017 · PMC5379526 · PMID 28372592

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of marginal significanceno p-value reported

Comparing the two foamy domains gives a Z-score of 2.077 sigma which, although of marginal significance, supports this model.

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highly significantno p-value reported

The degree of similarity between the domains ranged from less than 1 σ to over 5 σ , with the latter (highly significant) result being obtained for both a swapped (NC) and forward (CC) combination.

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clearly significantno p-value reported

These values indicated a clearly significant relationship between the foamy and ortho CA structures.

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marginally significantno p-value reported

T-test statistic: An alternative to the above analysis, which still remains marginally significant, is to pool the raw comparison data for all the domain comparisons and their background distributions giving now not just a single value compared to a distribution but two distributions (Fig. 9 b ).

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