Dynamic changes in heparan sulfate during muscle differentiation and ageing regulate myoblast cell fate and FGF2 signalling.

2 A), we observed an overall increase in 6-O-sulfation in the quadriceps of older mice (1-year- and 2-year-old) compared to young mice (3-month-old), while 2-O-sulfation only showed a trend towards a decrease that did not reach statistical significance ( Fig. 2 B).

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When the relative abundance of mono-sulfated, di-sulfated and tri-sulfated disaccharides was quantified, we observed a statistically significant increase in mono-sulfated disaccharides, which was accompanied by a marked decrease in non-sulfated disaccharides though the latter did not reach statistical significance ( Fig. 1 D).

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