Genetic modifiers of CHEK2*1100delC-associated breast cancer risk.

These two estimates in the CHEK2 *1100delC carriers alone did not reach statistical significance ( Table 1 ), possibly reflecting limited statistical power due to the relatively low number of healthy variant carriers ( Table S2 ).

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When altogether 77 common variants were considered individually, we found nominally significant interactions between five variants and CHEK2 *1100delC for overall breast cancer (rs11249433, rs11780156, rs204247, rs2981582 and rs704010; Table S4a ).

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