A152T tau allele causes neurodegeneration that can be ameliorated in a zebrafish model by autophagy induction.

Brain · 2017 · PMC5382950 · PMID 28334843

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hedged sentences

0.0180

closest p · 0.4× alpha

0.0630

boldest claim

The sentences

nominally significantP = 0.0180actually significant

However, the association was only significant for the PSP-S (OR = 8.13, CI: 2.77–22.99, Fisher’s exact test, P = 8.43 × 10 −5 ) cohort and nominally significant for the FTD (OR = 3.35, CI: 1.08–9.79, Fisher’s exact test, P = 0.0180) cohort.

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of borderline significanceP = 0.063so close (0.05 < p ≤ 0.1)

(2016) did not show a significant association between p.A152T and Alzheimer’s disease, and the association with FTD was of borderline significance (OR = 2.03; 95% CI = 0.95–4.34 P = 0.063) ( Pastor et al. , 2016 ).

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approached significanceP = 0.063so close (0.05 < p ≤ 0.1)

Together, these studies suggest that p.A152T is a risk factor for diverse neurodegenerative disease syndromes related to FTLD-tau and possibly synucleinopathy, although recently, a study of 11 572 subjects in Spain did not observe an increased association between p.A152T and Alzheimer’s disease, while the association with FTD spectrum approached significance [odds ratio (OR) = 2.03; P = 0.063] ( Pastor et al. , 2016 ).

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