<i>HSD17B12</i> gene rs11037575 C>T polymorphism confers neuroblastoma susceptibility in a Southern Chinese population.

We then combined risk genotypes and found a significant trend toward an increased neuroblastoma risk with the accumulation of risk genotypes (adjusted OR =1.26, 95% CI =1.01–1.58, P =0.043).

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The rs2619046 allele A (frequency of 0.52 and 0.47 in cases and controls, respectively) showed a trend toward the association with risk of neuroblastoma development ( P =0.087, OR =1.202, 95% CI =0.973–1.484) as previously reported in Italians and American Europeans. 18 , 20 These results were in accordance with the findings from previous GWAS study. 18 To the best of our knowledge, this is the first investigation to validate the association of neuroblastoma risk with GWAS-identified SNPs within the DUSP12, IL31RA, DDX4 , and HSD17B12 genes in a Southern Chinese population.

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