<i>In Vitro</i> and <i>In Vivo</i> Profile of PPL-101 and PPL-103: Mixed Opioid Partial Agonist Analgesics with Low Abuse Potential.

Front Psychiatry · 2017 · PMC5388777 · PMID 28446883

Europe PMC DOI

hedged sentences

0.0700

closest p · 1.4× alpha

0.0700

boldest claim

The sentences

showed a trendP = 0.07so close (0.05 < p ≤ 0.1)

Although by days 3–7 the 0.9% saline and PPL groups were very similar, the 0.9% saline replacement group only showed a trend toward a difference compared to the morphine group ( P = 0.07).

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a marked trendno p-value reported

PPL-101 (0.3–3.0 mg/kg; Figure 7 ) showed a marked trend to reduce operant responding for morphine.

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