Efficacy and safety of aspirin in patients with peripheral vascular disease: An updated systematic review and meta-analysis of randomized controlled trials.

However, these recommendations were based mainly on 3 studies: a single randomized trial [ 22 ] which had a high risk of bias by the Cochrane risk assessment tool; a meta-analysis by Berger et al [ 7 ] that showed a trend of reduction in the composite of MI, nonfatal stroke, and cardiovascular death with aspirin that did not reach statistical significance; together with older evidence from the Antithrombotic Trialists’ Collaboration (ATC) meta-analysis [ 4 ].

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