TP53-based interaction analysis identifies cis-eQTL variants for TP53BP2, FBXO28, and FAM53A that associate with survival and treatment outcome in breast cancer.

Oncotarget · 2017 · PMC5392336 · PMID 28179588

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closest p · 0.8× alpha

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boldest claim

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nominally significantp = 0.04actually significant

The interaction remained statistically significant (p = 2.6 × 10-4) when adjuvant endocrine therapy was included in the Cox model, and the interaction exists at a nominally significant level even among ER-positive cases not treated with endocrine therapy (n = 843, 140 events, p = 0.04).

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did not reach statistical significancep = 0.04actually significant

The same was seen in the HEBCS-GWS data set, even though the interactions themselves did not reach statistical significance in either ER-based subgroup (heterogeneity p = 0.04).

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