EED orchestration of heart maturation through interaction with HDACs is H3K27me3-independent.

Despite this potential survivor bias, heart function rescue by AAV9-EED tended to impair AAV9-EED rescue in the remaining three mice, although this did not reach statistical significance (p=0.07; Figure 6A,B ).

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Immunoblotting of purified Eed CKO CMs showed that Eed inactivation markedly increased total histone H4 acetylation and acetylation of histone H3 at K9 and K27 ( Figure 2A ); H3K14ac showed a trend toward being higher in Eed CKO , although the difference was not statistically significant (p=0.074; Figure 2A ).

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