showed a trendP = 0.146
The difference between the two groups showed a trend towards improvement (P = 0.146).
The difference between the two groups showed a trend towards improvement (P = 0.146).
When comparing the ITT and post hoc analysis data, it is obvious that (i) qualitatively, both sets show a virtually identical time course of ACR—the specific beneficial effect sets in 2 months after start of treatment, improves further until end of treatment and is maintained after cessation of dosing; (ii) quantitatively, the placebo-corrected effect of emapticap on ACR is most pronounced and statistically significant in the post hoc analysis, and maintained at least as a clear trend in the ITT population; and (iii) the improved separation in ACR between emapticap and placebo in the post hoc analysis is mainly due to reduced background noise in the placebo group.