A novel approach to PTSD modeling in rats reveals alternating patterns of limbic activity in different types of stress reaction.

One-way ANOVA showed that anhedonic rats had a mildly significant trend of enhanced freezing behavior during the pretrauma habituation to the WAZM (F (3,41) =2.5, P =0.072; Figure 7a ).

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In line with the model's predictions, the anhedonic phenotype showed a trend for enhanced reflexive fear behavior before the UWT exposure ( Figure 7a ), as well as a prominent decrease in the averaged preference for saccharin ( Figure 7b ), which gradually became evident after the UWT exposure (see Supplementary Figure S3e ).

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