Efficacy of CR4056, a first-in-class imidazoline-2 analgesic drug, in comparison with naproxen in two rat models of osteoarthritis.

J Pain Res · 2017 · PMC5422496 · PMID 28496359

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did not reach statistical significanceno p-value reported

Conversely, when testing naproxen for anti-hyperalgesic efficacy after acute administration, we found only a trend of efficacy that did not reach statistical significance, contrary to CR4056.

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showed a trendno p-value reported

CR4056 (6 mg/kg) induced also a significant reversal of MIA-induced hyperalgesia (day 14) ( Figure 2 ), whereas naproxen and the lower dose of CR4056 showed a trend of efficacy not reaching statistical significance.

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