Blood RNA biomarkers in prodromal PARK4 and rapid eye movement sleep behavior disorder show role of complexin 1 loss for risk of Parkinson's disease.

Dis Model Mech · 2017 · PMC5451169 · PMID 28108469

Europe PMC DOI

hedged sentences

0.0600

closest p · 1.2× alpha

0.0800

boldest claim

The sentences

a statistical trendP =0.06so close (0.05 < p ≤ 0.1)

By contrast, a significant downregulation was confirmed for the CPLX1 transcript (to 74%, P =0.015; upon exclusion of one exceptionally high value among controls, a statistical trend towards downregulation with P =0.06 remained; Fig. 4 B).

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showed a trendP =0.08so close (0.05 < p ≤ 0.1)

The PARK4 cohort showed a trend towards reduced CPLX1 values at older age ( P =0.08) and a trend towards lower values in females ( P =0.08).

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nominally significantno p-value reported

A nominally significant inverse correlation was observed for CPLX1 and a trend towards inverse correlation for YWHAE ( Fig. 2 B), two phenomena that we had previously identified as synucleinopathy markers in mouse mutant midbrain (Gispert et al., 2015b; Brehm et al., 2015a ).

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