Cerebrospinal fluid microRNAs are potential biomarkers of temporal lobe epilepsy and status epilepticus.

Finally, as the significantly differentially expressed microRNAs between the control and TLE samples all had borderline significant p -value, and none of them had a log 2 -fold change above 2, we chose miR-223-3p as it has been shown to be expressed in astrocytes and microglia 22 .

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The levels of miR-451a obtained from plasma showed a trend toward negative correlation with the levels in the same individual in CSF, although this did not reach statistical significance (ρ = −0.75, p = 0.066) (Fig.

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