Geographic variation in pneumococcal vaccine efficacy estimated from dynamic modeling of epidemiological data post-PCV7.

Although this trend did not reach statistical significance with these datasets, it is not surprising, given that serotype-specific vaccine protection and serotype-specific protection waning rates have been reported for PCV7 73 .

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When accounting for the fact that vaccine-induced immunity against serotype 19F is weaker than that against other PCV7 serotypes 74 , 75 , a negative trend became apparent between variable initial prevalence of 19F (the difficult serotype) at the beginning of the study period, and the resulting variable apparent protection against PCV7 serotypes when pooled together.

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