Results showed that although there was a trend of increase in the ratio of p-ERK/actin and p-ERK/ERK expression levels of the BTBR animals compared with B6 mice, the differences did not reach statistical significance, and large variations among the BTBR samples were observed.
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Dendritic overgrowth and elevated ERK signaling during neonatal development in a mouse model of autism.
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The relative level of total MEK was also increased, while the level of total ERK as well as the ratios of p-MEK to MEK and p-ERK to ERK showed a trend of increase ( Fig 4 ).