Neural correlates of emotion acceptance vs worry or suppression in generalized anxiety disorder.

Ratings between Accept and Suppress approached significance [ t (20) = 1.84, P = 0.08, Cohen’s d = 0.82].

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A moderate effect was also found for the Accept condition in the expected direction, but this did not reach statistical significance [β = −0.34, t (19) = −1.54, P = 0.14; R 2 = 0.12, F (1, 20) = 2.36, P = 0.14]. fMRI results Regulation using Worry Large effect size (Cohen’s d ) differences were found in early phase responses to the Worry regulation instructions relative to Accept regulation instructions in right VLPFC (BA 47, Figure 2A and B ) and left precuneus (BA 31), with Worry evidencing significantly greater activation than Accept.

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